Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons.

doi:10.1038/nn.2922

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Article

Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons.

Nature neuroscience - 28 Aug 2011

Tian Xiaolin, Li Jing, Valakh Vera, DiAntonio Aaron, Wu Chunlai

Abstract excerpt

The evolutionarily conserved Highwire (Hiw)/Drosophila Fsn E3 ubiquitin ligase complex is required for normal synaptic morphology during development and axonal regeneration after injury. However, little is known about the molecular mechanisms that regulate the Hiw E3 ligase complex. Using tandem affinity purification techniques, we identified Drosophila Rae1 as a previously unknown component of the Hiw/Fsn...

Topics

Animals
Animals, Genetically Modified
Autophagy
Cell Cycle
Chromatography, Liquid
Drosophila
Drosophila Proteins
Gene Expression Regulation
Green Fluorescent Proteins
Larva
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nerve Tissue Proteins

Neuromuscular Junction

Neurons

Nuclear Matrix-Associated Proteins

Nucleocytoplasmic Transport Proteins

Presynaptic Terminals

Protein Binding

Source

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Identifiers

PMID: 21874015
DOI: 10.1038/nn.2922
PMCID: PMC3183334

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Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons.PMID 21874015Read ↗

Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements.Semantic proximity Read ↗

DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth.Semantic proximity Read ↗

The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein.Semantic proximity Read ↗

Highwire regulates presynaptic BMP signaling essential for synaptic growth.Semantic proximity Read ↗

SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury.Semantic proximity Read ↗

Highwire regulates guidance of sister axons in the Drosophila mushroom body.Semantic proximity Read ↗

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury.Semantic proximity Read ↗

Highwire regulates synaptic growth in Drosophila.Semantic proximity Read ↗

Axon Termination, Pruning, and Synaptogenesis in the Giant Fiber System of Drosophila melanogaster Is Promoted by Highwire.Semantic proximity Read ↗

The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repressionSemantic proximity Read ↗

A mechanism distinct from highwire for the Drosophila ubiquitin conjugase bendless in synaptic growth and maturation.Semantic proximity Read ↗

Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila.Semantic proximity Read ↗

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