Article
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.
Nature neuroscience - 1 Dec 2001
Mack T G, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, Thomson D, Gillingwater T, Court F, Conforti L, Fernando F S, Tarlton A, Andressen C, Addicks K, Magni G, Ribchester R R, Perry V H, Coleman M P
Abstract excerpt
Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are protected. The degenerative and protective mechanisms are unknown. We identified the protective gene, which encodes an N-terminal fragment of ubiquitination factor E4B (Ube4b) fused to nicotinamide mononucleotide adenylyltransferase (Nmnat), and showed that it confers a dose-dependent block of...
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