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Article

SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Jun 2014

Brace E J, Wu Chunlai, Valakh Vera, DiAntonio Aaron

Abstract excerpt

The Wallenda (Wnd)/dual leucine zipper kinase (DLK)-Jnk pathway is an evolutionarily conserved MAPK signaling pathway that functions during neuronal development and following axonal injury. Improper pathway activation causes defects in axonal guidance and synaptic growth, whereas loss-of-function mutations in pathway components impairs axonal regeneration and degeneration after injury. Regulation of this pathway...

Topics

Animals
Animals, Genetically Modified
Axons
Drosophila Proteins
Drosophila melanogaster
Female
Male
Mutation
Nerve Degeneration
Presynaptic Terminals
SKP Cullin F-Box Protein Ligases

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Synapses

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Identifiers

PMID: 24948796
DOI: 10.1523/JNEUROSCI.4715-13.2014
PMCID: PMC4061385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury.PMID 24948796Read ↗

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