Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wld(S), Nmnats and axon degeneration--progress in the past two decades.

Protein & cell - 1 Mar 2010

Feng Yan, Yan Tingting, He Zhigang, Zhai Qiwei

Abstract excerpt

A chimeric protein called Wallerian degeneration slow (Wld(S)) was first discovered in a spontaneous mutant strain of mice that exhibited delayed Wallerian degeneration. This provides a useful tool in elucidating the mechanisms of axon degeneration. Over-expression of Wld(S) attenuates the axon degeneration that is associated with several neurodegenerative disease models, suggesting a new logic for developing a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Mice
Share to Mice, Mutant Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Neurological

Share to Mutant Proteins

Share to Nerve Degeneration

Share to Nerve Tissue Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21203970
DOI: 10.1007/s13238-010-0021-2
PMCID: PMC4875081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wld(S), Nmnats and axon degeneration--progress in the past two decades.PMID 21203970Read ↗

NAD and axon degeneration: From the Wlds gene to neurochemistrySemantic proximity Read ↗

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.Semantic proximity Read ↗

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate ImmunitySemantic proximity Read ↗

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration<i>In Vivo</i>Semantic proximity Read ↗

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.Semantic proximity Read ↗

NAD+ and axon degeneration revisited: Nmnat1 cannot substitute for WldS to delay Wallerian degenerationSemantic proximity Read ↗

Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function.Semantic proximity Read ↗

The NAD <sup>+</sup> precursor NMN activates dSarm to trigger axon degeneration in <i>Drosophila</i>Semantic proximity Read ↗

WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.Semantic proximity Read ↗

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degenerationSemantic proximity Read ↗

Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis ActivitySemantic proximity Read ↗

Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.