Article

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in mice

2022-02-09

Abstract excerpt

<h4>Background</h4> Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) in CNS neurons. NMNAT2 mRNA levels are reduced in the brains of Alzheimer’s, Parkinson’s and Huntington’s disease. Here we a...

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Literature Corpus work: 5cce5090-7696-57ac-8f83-265921dc054e
DOI: 10.1101/2022.02.06.479307

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