Article

The NAD <sup>+</sup> precursor NMN activates dSarm to trigger axon degeneration in <i>Drosophila</i>

2022-01-30

Abstract excerpt

Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activation of SARM1 in mammals to execute the pathological depletion of the metabolite NAD + . SARM1 NADase activity is activated by the NAD + precursor nicotinamide mononuc...

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Literature Corpus work: e8f13bbb-80df-525e-84a7-fa9c1dca55e7
DOI: 10.1101/2022.01.30.478002

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