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Article

Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity

22 Nov 2006

Abstract excerpt

Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wld(s)) mice overexpress a chimeric protein containing the NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase 1) and exhibit a delay in axonal degeneration. Currently, conflicting evidence raises questions as to whether NMNAT is the protecting factor and whether its enzymatic...

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PMID: 17132048
DOI: 10.1371/journal.pbio.0040416

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Related research

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Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis ActivityPMID 17132048Read ↗

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