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Article

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.

Science (New York, N.Y.) - 13 Aug 2004

Araki Toshiyuki, Sasaki Yo, Milbrandt Jeffrey

Abstract excerpt

Axonal degeneration is an active program of self-destruction that is observed in many physiological and pathological settings. In Wallerian degeneration slow (wlds) mice, Wallerian degeneration in response to axonal injury is delayed because of a mutation that results in overexpression of a chimeric protein (Wlds) composed of the ubiquitin assembly protein Ufd2a and the nicotinamide adenine dinucleotide (NAD)...

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Identifiers

PMID: 15310905
DOI: 10.1126/science.1098014

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.PMID 15310905Read ↗

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Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration<i>In Vivo</i>Semantic proximity Read ↗

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The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein.Semantic proximity Read ↗

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degenerationSemantic proximity Read ↗

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