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Article

A yeast tRNA mutant that causes pseudohyphal growth exhibits reduced rates of CAG codon translation.

Molecular microbiology - 1 Jan 2013

Kemp Alain J, Betney Russell, Ciandrini Luca, Schwenger Alexandra C M, Romano M Carmen, Stansfield Ian

Abstract excerpt

In Saccharomyces cerevisiae, the SUP70 gene encodes the CAG-decoding tRNA(Gln)(CUG). A mutant allele, sup70-65, induces pseudohyphal growth on rich medium, an inappropriate nitrogen starvation response. This mutant tRNA is also a UAG nonsense suppressor via first base wobble. To investigate the basis of the pseudohyphal phenotype, 10 novel sup70 UAG suppressor alleles were identified, defining positions in the...

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Identifiers

PMID: 23146061
DOI: 10.1111/mmi.12096
PMCID: PMC3664417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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