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Article

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.

Biomolecules - 18 Feb 2020

Pollo-Oliveira Leticia, Klassen Roland, Davis Nick, Ciftci Akif, Bacusmo Jo Marie, Martinelli Maria, DeMott Michael S, Begley Thomas J, Dedon Peter C, Schaffrath Raffael, de Crécy-Lagard Valérie

Abstract excerpt

Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t6A37) and 5-methoxycarbonyl methyl-2-thiouridine (mcm5s2U34) are critical ASL modifications that have been linked to several human diseases. The model yeast Saccharomyces cerevisiae is viable despite the absence of both modifications, growth is however...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32085421
DOI: 10.3390/biom10020322
PMCID: PMC7072221

Genes

ASL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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