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Article

Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis.

Genes & development - 1 Aug 2014

Guy Michael P, Young David L, Payea Matthew J, Zhang Xiaoju, Kon Yoshiko, Dean Kimberly M, Grayhack Elizabeth J, Mathews David H, Fields Stanley, Phizicky Eric M

Abstract excerpt

Sequence variation in tRNA genes influences the structure, modification, and stability of tRNA; affects translation fidelity; impacts the activity of numerous isodecoders in metazoans; and leads to human diseases. To comprehensively define the effects of sequence variation on tRNA function, we developed a high-throughput in vivo screen to quantify the activity of a model tRNA, the nonsense suppressor SUP4oc of...

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Identifiers

PMID: 25085423
DOI: 10.1101/gad.245936.114
PMCID: PMC4117946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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