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The molecular aetiology of tRNA synthetase depletion: induction of a <i>GCN4</i> amino acid starvation response despite homeostatic maintenance of charged tRNA levels

2019-04-16

Abstract excerpt

<h4>ABSTRACT</h4> During protein synthesis, charged tRNAs deliver amino acids to translating ribosomes, and are then re-charged by tRNA synthetases (aaRS). In humans, mutant aaRS cause a diversity of neurological disorders, but their molecular aetiologies are incompletely characterised. To understand system responses to aaRS depletion, the yeast glutamine aaRS gene ( GLN4 ) was transcriptionally regulated using...

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Literature Corpus work
33364fe4-cc62-579c-b7c7-d8091329f4b6
DOI
10.1101/610790
Open publication

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