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Article

Loss of a conserved tRNA anticodon modification perturbs cellular signaling.

PLoS genetics - 1 Jan 2013

Zinshteyn Boris, Gilbert Wendy V

Abstract excerpt

Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of translation in all organisms. The anticodon modification mcm(5)s(2)U(34) is required for normal growth and stress resistance in yeast; mutants lacking this modification have numerous phenotypes. Mutations in the homologous human genes are linked to neurological disease. The yeast phenotypes can be ameliorated by overexpression...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23935536
DOI: 10.1371/journal.pgen.1003675
PMCID: PMC3731203

Genes

GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Loss of a conserved tRNA anticodon modification perturbs cellular signaling.PMID 23935536Read ↗

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