Article
Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae.
PloS one - 13 Jun 2007
Plant Ewan P, Nguyen Phuc, Russ Jonathan R, Pittman Yvette R, Nguyen Thai, Quesinberry Jack T, Kinzy Terri Goss, Dinman Jonathan D
Abstract excerpt
BACKGROUND: Decoding of mRNAs is performed by aminoacyl tRNAs (aa-tRNAs). This process is highly accurate, however, at low frequencies (10(-3) - 10(-4)) the wrong aa-tRNA can be selected, leading to incorporation of aberrant amino acids. Although our understanding of what constitutes the correct...
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