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Article

Evolving Mistranslating tRNAs Through a Phenotypically Ambivalent Intermediate in Saccharomyces cerevisiae.

Genetics - 1 Aug 2017

Berg Matthew D, Hoffman Kyle S, Genereaux Julie, Mian Safee, Trussler Ryan S, Haniford David B, O'Donoghue Patrick, Brandl Christopher J

Abstract excerpt

The genetic code converts information from nucleic acid into protein. The genetic code was thought to be immutable, yet many examples in nature indicate that variations to the code provide a selective advantage. We used a sensitive selection system involving suppression of a deleterious allele (tti2-L187P) in Saccharomyces cerevisiae to detect mistranslation and identify mechanisms that allow genetic code...

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Identifiers

PMID: 28576863
DOI: 10.1534/genetics.117.203232
PMCID: PMC5560794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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