Article
Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation.
Nucleic acids research - 2 Nov 2016
Gorgoni Barbara, Ciandrini Luca, McFarland Matthew R, Romano M Carmen, Stansfield Ian
Abstract excerpt
tRNA gene copy number is a primary determinant of tRNA abundance and therefore the rate at which each tRNA delivers amino acids to the ribosome during translation. Low-abundance tRNAs decode rare codons slowly, but it is unclear which genes might be subject to tRNA-mediated regulation of expression. Here, those mRNA targets were identified via global simulation of translation. In-silico mRNA translation rates...
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