Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability.

doi:10.1101/gr.141382.112

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Article

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability.

Genome research - 1 Feb 2013

Drier Yotam, Lawrence Michael S, Carter Scott L, Stewart Chip, Gabriel Stacey B, Lander Eric S, Meyerson Matthew, Beroukhim Rameen, Getz Gad

Abstract excerpt

Whole-genome sequencing using massively parallel sequencing technologies enables accurate detection of somatic rearrangements in cancer. Pinpointing large numbers of rearrangement breakpoints to base-pair resolution allows analysis of rearrangement microhomology and genomic location for every sample. Here we analyze 95 tumor genome sequences from breast, head and neck, colorectal, and prostate carcinomas, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23124520
DOI: 10.1101/gr.141382.112
PMCID: PMC3561864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.