Article
Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution.
Genome research - 1 Sept 2007
Bignell Graham R, Santarius Thomas, Pole Jessica C M, Butler Adam P, Perry Janet, Pleasance Erin, Greenman Chris, Menzies Andrew, Taylor Sheila, Edkins Sarah, Campbell Peter, Quail Michael, Plumb Bob, Matthews Lucy, McLay Kirsten, Edwards Paul A W, Rogers Jane, Wooster Richard, Futreal P Andrew, Stratton Michael R
Abstract excerpt
For decades, cytogenetic studies have demonstrated that somatically acquired structural rearrangements of the genome are a common feature of most classes of human cancer. However, the characteristics of these rearrangements at sequence-level resolution have thus far been subject to very limited description. One process that is dependent upon somatic genome rearrangement is gene amplification, a mechanism often...
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