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Cancer cells are uniquely susceptible to accumulation of MMBIR mutations

2020-07-19

Abstract excerpt

Microhomology-mediated break-induced replication (MMBIR) is a mechanism of polymerase template switching at microhomology, which can produce complex genomic rearrangements (CGRs), underlies neurological and metabolic diseases, and contributes to cancer development. Yet, the extent of MMBIR activity in genomes is poorly understood due to difficulty in directly identifying MMBIR events by whole genome sequencing (WG...

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Literature Corpus work
c9f6825b-078c-5b93-a22b-01d279116d59
DOI
10.1101/2020.07.19.209445
Open publication

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Cancer cells are uniquely susceptible to accumulation of MMBIR mutationsDOI 10.1101/2020.07.19.209445
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