Article

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

2018-05-30

Abstract excerpt

<h4>Summary</h4> Chromothripsis is a newly discovered mutational phenomenon involving massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in cancer suggest that chromothripsis may be far more common than initially inferred from low resolution DNA copy number data. Here, we analyze the patterns of chromothripsis across 2,658 tumors spanning 39 cancer types using whole...

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Literature Corpus work: dc7c3ec8-1f56-5188-937c-3258cf5c8ce5
DOI: 10.1101/333617

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