Article
Germline determinants of the somatic mutation landscape in 2,642 cancer genomes
2017-11-01
Abstract excerpt
Cancers develop through somatic mutagenesis, however germline genetic variation can markedly contribute to tumorigenesis via diverse mechanisms. We discovered and phased 88 million germline single nucleotide variants, short insertions/deletions, and large structural variants in whole genomes from 2,642 cancer patients, and employed this genomic resource to study genetic determinants of somatic mutagenesis across 3...
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Identifiers and source
- Literature Corpus work
- 0e70c54a-574b-5638-8e31-f5c7f14bd59d
- DOI
- 10.1101/208330