Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure.

doi:10.1038/s41588-020-0708-0

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Article

Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure.

Nature genetics - 1 Nov 2020

Akdemir Kadir C, Le Victoria T, Kim Justin M, Killcoyne Sarah, King Devin A, Lin Ya-Ping, Tian Yanyan, Inoue Akira, Amin Samirkumar B, Robinson Frederick S, Nimmakayalu Manjunath, Herrera Rafael E, Lynn Erica J, Chan Kin, Seth Sahil, Klimczak Leszek J, Gerstung Moritz, Gordenin Dmitry A, O'Brien John, Li Lei, Deribe Yonathan Lissanu, Verhaak Roel G, Campbell Peter J, Fitzgerald Rebecca, Morrison Ashby J, Dixon Jesse R, Andrew Futreal P

Abstract excerpt

Somatic mutations in driver genes may ultimately lead to the development of cancer. Understanding how somatic mutations accumulate in cancer genomes and the underlying factors that generate somatic mutations is therefore crucial for developing novel therapeutic strategies. To understand the interplay between spatial genome organization and specific mutational processes, we studied 3,000 tumor-normal-pair...

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PMID: 33020667
DOI: 10.1038/s41588-020-0708-0
PMCID: PMC8350746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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