Article
Patterns of somatic structural variation in human cancer genomes.
Nature - 1 Feb 2020
Li Yilong, Roberts Nicola D, Wala Jeremiah A, Shapira Ofer, Schumacher Steven E, Kumar Kiran, Khurana Ekta, Waszak Sebastian, Korbel Jan O, Haber James E, Imielinski Marcin, Weischenfeldt Joachim, Beroukhim Rameen, Campbell Peter J
Abstract excerpt
A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes1-7. Here we develop methods to group, classify and describe somatic structural variants, using data from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer...
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