Article
Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms.
Genome research - 1 May 2013
Malhotra Ankit, Lindberg Michael, Faust Gregory G, Leibowitz Mitchell L, Clark Royden A, Layer Ryan M, Quinlan Aaron R, Hall Ira M
Abstract excerpt
Tumor genomes are generally thought to evolve through a gradual accumulation of mutations, but the observation that extraordinarily complex rearrangements can arise through single mutational events suggests that evolution may be accelerated by punctuated changes in genome architecture. To assess the prevalence and origins of complex genomic rearrangements (CGRs), we mapped 6179 somatic structural variation...
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