Article
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.
Molecular psychiatry - 1 Jan 2014
Davies G, Harris S E, Reynolds C A, Payton A, Knight H M, Liewald D C, Lopez L M, Luciano M, Gow A J, Corley J, Henderson R, Murray C, Pattie A, Fox H C, Redmond P, Lutz M W, Chiba-Falek O, Linnertz C, Saith S, Haggarty P, McNeill G, Ke X, Ollier W, Horan M, Roses A D, Ponting C P, Porteous D J, Tenesa A, Pickles A, Starr J M, Whalley L J, Pedersen N L, Pendleton N, Visscher P M, Deary I J
Abstract excerpt
Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age. We investigated the genetic contribution to individual differences in nonpathological cognitive ageing in five cohorts of older adults. We undertook a genome-wide association analysis using 549 692 single-nucleotide polymorphisms (SNPs) in 3511 unrelated adults in the...
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