Article
TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2013
Roses Allen D, Lutz Michael W, Crenshaw Donna G, Grossman Iris, Saunders Ann M, Gottschalk W Kirby
Abstract excerpt
A number of recent studies have not replicated the association of the translocase of the outer mitochondrial membrane pore subunit (TOMM40) rs10524523 polymorphism, which is in linkage disequilibrium with apolipoprotein E (APOE), with age of onset of Alzheimer's disease (AD). This perspective describes the differences between these later studies and the original experiments. We highlight the necessity for using...
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