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Article

Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.

PloS one - 1 Jan 2012

Schneider Patricia N, Slusarski Diane C, Houston Douglas W

Abstract excerpt

Axin is a critical component of the β-catenin destruction complex and is also necessary for Wnt signaling initiation at the level of co-receptor activation. Axin contains an RGS domain, which is similar to that of proteins that accelerate the GTPase activity of heterotrimeric Gα/Gna proteins and thereby limit the duration of active G-protein signaling. Although G-proteins are increasingly recognized as essential...

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Identifiers

PMID: 22957046
DOI: 10.1371/journal.pone.0044096
PMCID: PMC3434218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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