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Article

Generation of Axin1 conditional mutant mice.

Genesis (New York, N.Y. : 2000) - 1 Feb 2011

Xie Rong, Jiang Rulang, Chen Di

Abstract excerpt

Axin1 is a critical negative regulator of the canonical Wnt-signaling pathway. It is a concentration-limiting factor in the β-catenin degradation complex. Axin1 null mutant mouse embryos died at embryonic day 9.5, precluding direct genetic analysis of the roles of Axin1 in many developmental and physiological processes using these mutant mice. In this study, we have generated mice carrying two directly repeated...

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Identifiers

PMID: 21344612
DOI: 10.1002/dvg.20703
PMCID: PMC3120898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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