Article
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.
Genes & development - 1 Jun 2001
Heisenberg C P, Houart C, Take-Uchi M, Rauch G J, Young N, Coutinho P, Masai I, Caneparo L, Concha M L, Geisler R, Dale T C, Wilson S W, Stemple D L
Abstract excerpt
Zebrafish embryos homozygous for the masterblind (mbl) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mbl(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of...
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