Article
Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant.
Development (Cambridge, England) - 1 Oct 2001
van de Water S, van de Wetering M, Joore J, Esseling J, Bink R, Clevers H, Zivkovic D
Abstract excerpt
masterblind (mbl) is a zebrafish mutation characterised by the absence or reduction in size of the telencephalon, optic vesicles and olfactory placodes. We show that inhibition of Gsk3beta in zebrafish embryos either by overexpression of dominant negative dn gsk3beta mRNA or by lithium treatment after the midblastula transition phenocopies mbl. The loss of anterior neural tissue in mbl and lithium-treated embryos...
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