Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.

Molecular biology of the cell - 1 Jul 2024

Bell Ian, Khan Haider, Stutt Nathan, Horn Matthew, Hydzik Teesha, Lum Whitney, Rea Victoria, Clapham Emma, Hoeg Lisa, Van Raay Terence J

Abstract excerpt

Wnt signaling is a crucial developmental pathway involved in early development as well as stem-cell maintenance in adults and its misregulation leads to numerous diseases. Thus, understanding the regulation of this pathway becomes vitally important. Axin2 and Nkd1 are widely utilized negative feedback regulators in Wnt signaling where Axin2 functions to destabilize cytoplasmic β-catenin, and Nkd1 functions to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Catenin

Share to Carrier Proteins

Share to Mutation

Share to Wnt Signaling Pathway

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38656801
DOI: 10.1091/mbc.E24-02-0059-T
PMCID: PMC11244159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.PMID 38656801Read ↗

Loss of Nkd1 is epistatic to loss of Axin2 in regulating Wnt signalingSemantic proximity Read ↗

Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling.Semantic proximity Read ↗

Nkd1 functions as a passive antagonist of Wnt signaling.Semantic proximity Read ↗

Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skinSemantic proximity Read ↗

The broad role of Nkx3.2 in the development of the zebrafish axial skeleton.Semantic proximity Read ↗

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.Semantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Nkx2.5-dependent alterations of the embryonic heart DNA methylome identify novel cis-regulatory elements in cardiac developmentSemantic proximity Read ↗

Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1.Semantic proximity Read ↗

Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.Semantic proximity Read ↗

Genetic analysis of attractin homologs.Semantic proximity Read ↗

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.