Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.

Developmental biology - 1 Aug 2008

Peterson-Nedry Wynne, Erdeniz Naz, Kremer Susan, Yu Jessica, Baig-Lewis Shahana, Wehrli Marcel

Abstract excerpt

Secreted proteins in the Wnt family regulate gene expression in target cells by causing the accumulation of the transcriptional activator beta-catenin. In the absence of Wnt, a protein complex assembled around the scaffold protein Axin targets beta-catenin for destruction, thereby preventing it from transducing inappropriate signals. Loss of Axin or its binding partners APC and GSK3 results in aberrant activation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Mutant Proteins

Share to Sequence Deletion

Share to Thermodynamics

Share to Wnt Proteins

Share to Wnt1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18561909
DOI: 10.1016/j.ydbio.2008.05.521
PMCID: PMC6037319

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.PMID 18561909Read ↗

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.Semantic proximity Read ↗

The effect of Wnt signaling on the localization, molecular size and activity of the beta-catenin destruction complex in vivoSemantic proximity Read ↗

Biochemical characterization of the Drosophila axin protein.Semantic proximity Read ↗

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled.Semantic proximity Read ↗

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.Semantic proximity Read ↗

Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.Semantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.Semantic proximity Read ↗

Mouse axin and axin2/conductin proteins are functionally equivalent in vivo.Semantic proximity Read ↗

Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling.Semantic proximity Read ↗

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.Semantic proximity Read ↗

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.