Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.

Genes & development - 15 May 2002

Korswagen Hendrik C, Coudreuse Damien Y M, Betist Marco C, van de Water Sandra, Zivkovic Danica, Clevers Hans C

Abstract excerpt

Axin, APC, and the kinase GSK3 beta are part of a destruction complex that regulates the stability of the Wnt pathway effector beta-catenin. In C. elegans, several Wnt-controlled developmental processes have been described, but an Axin ortholog has not been found in the genome sequence and SGG-1/GSK3 beta, and the APC-related protein APR-1 have been shown to act in a positive, rather than negative fashion in Wnt...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinases

Share to Glycogen Synthase Kinase 3

Share to Helminth Proteins

Share to High Mobility Group Proteins

Share to Tissue Inhibitor of Metalloproteinase-3

Share to Tissue Inhibitor of Metalloproteinases

Source

Open in PubMed Open full text

Identifiers

PMID: 12023307
DOI: 10.1101/gad.981802
PMCID: PMC186271

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.PMID 12023307Read ↗

A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans.Semantic proximity Read ↗

Conserved mechanism of Wnt signaling function in the specification of vulval precursor fates in C. elegans and C. briggsae.Semantic proximity Read ↗

A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons.Semantic proximity Read ↗

Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction.Semantic proximity Read ↗

Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways.Semantic proximity Read ↗

Genetic analysis of <i>Caenorhabditis elegans pry-1/Axin</i> suppressors identifies genes involved in reproductive structure development, stress response, and agingSemantic proximity Read ↗

The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.Semantic proximity Read ↗

lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.Semantic proximity Read ↗

Loss-of-function of β-catenin bar-1 slows development and activates the Wnt pathway in Caenorhabditis elegans.Semantic proximity Read ↗

A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans.Semantic proximity Read ↗

Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skinSemantic proximity Read ↗

lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.