Article
Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 2011
Qian Lihui, Mahaffey James P, Alcorn Heather L, Anderson Kathryn V
Abstract excerpt
Axin proteins are key negative regulators of the canonical Wnt signal transduction pathway. Although Axin2 null mice are viable, we identified an unusual ENU-induced recessive allele of Axin2, canp, that causes midgestation lethality in homozygotes. We show that the Axin2(canp) mutation is a V26D substitution in an invariant N-terminal sequence motif and that the Axin2(canp) protein is more stable than wild type....
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