Article
Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling.
The Journal of biological chemistry - 9 May 2008
Lu Zailian, Liu Wei, Huang Huizhe, He Ying, Han Ying, Rui Yanning, Wang Yanhai, Li Qinxi, Ruan Ka, Ye Zhiyun, Low Boon Chuan, Meng Anming, Lin Sheng-Cai
Abstract excerpt
Axin plays an architectural role in many important signaling pathways that control various aspects of development and tumorigenesis, including the Wnt, transforming growth factor-beta, MAP kinase pathways, as well as p53 activation cascades. It is encoded by the mouse Fused (Fu) locus; the Axin(F...
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