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Article

Mouse axin and axin2/conductin proteins are functionally equivalent in vivo.

Molecular and cellular biology - 1 Jun 2005

Chia Ian V, Costantini Frank

Abstract excerpt

Axin is a central component of the canonical Wnt signal transduction machinery, serving as a scaffold for the beta-catenin destruction complex. The related protein Axin2/Conductin, although less extensively studied, is thought to perform similar functions. Loss of Axin causes early embryonic lethality, while Axin2-null mice are viable but have craniofacial defects. Mutations in either gene contribute to cancer in...

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Identifiers

PMID: 15899843
DOI: 10.1128/MCB.25.11.4371-4376.2005
PMCID: PMC1140612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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