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Article

The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish.

The Journal of biological chemistry - 13 Apr 2012

Li Zhiqiang, Wang Yeqi, Zhang Min, Xu Pengfei, Huang Huizhe, Wu Di, Meng Anming

Abstract excerpt

The Motin family proteins can regulate cell polarity, cell mobility, and proliferation during embryonic development by controlling distinct signaling pathways. In this study, we demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer β-catenin2. Overexpression of amotl2 in masterblind (mbl)...

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Identifiers

PMID: 22362771
DOI: 10.1074/jbc.M112.347419
PMCID: PMC3339985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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