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Article

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.

Genetics - 1 May 2016

Wang Zhenghan, Tacchelly-Benites Ofelia, Yang Eungi, Thorne Curtis A, Nojima Hisashi, Lee Ethan, Ahmed Yashi

Abstract excerpt

Wnt/β-catenin signal transduction directs metazoan development and is deregulated in numerous human congenital disorders and cancers. In the absence of Wnt stimulation, a multiprotein "destruction complex," assembled by the scaffold protein Axin, targets the key transcriptional activator β-catenin for proteolysis. Axin is maintained at very low levels that limit destruction complex activity, a property that is...

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PMID: 26975665
DOI: 10.1534/genetics.115.183244
PMCID: PMC4858779

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APC

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Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.PMID 26975665Read ↗

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