Article
Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study.
Molecular biology reports - 1 Oct 2012
Zhang Yuxing, Liu Li, Tang Yingchun, Chen Chao, Wang Qian, Xu Jun, Yang Chao, Miao Xiaoping, Wei Sheng, Chen Jigui, Nie Shaofa
Abstract excerpt
The murine double minute 2 protein (MDM2) and TP53 interact in regulating cell cycle, DNA repair and apoptosis process, which is crucial in carcinogenesis. Since functional variations in these two genes were shown to change gene expression and function, we hypothesized that potentially functional polymorphisms in these genes may contribute to colorectal cancer (CRC) susceptibility. A hospital-based case-control...
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