P53 Arg72Pro and MDM2 SNP309 polymorphisms cooperate to increase lung adenocarcinoma risk in Chinese female non-smokers: a case control study.

doi:10.7314/apjcp.2013.14.9.5415

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Article

P53 Arg72Pro and MDM2 SNP309 polymorphisms cooperate to increase lung adenocarcinoma risk in Chinese female non-smokers: a case control study.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Ren Yang-Wu, Yin Zhi-Hua, Wan Yan, Guan Peng, Wu Wei, Li Xue-Lian, Zhou Bao-Sen

Abstract excerpt

BACKGROUND: Cell cycle deregulation is a major component of carcinogenesis. The p53 tumor suppressor gene plays an important role in regulating cell cycle arrest, and mouse double minute 2 (MDM2) is a key regulator of p53 activity and degradation. Abnormal expression of p53 and MDM2 occurs in various cancers including lung cancer. METHODS: We investigated the distribution of the p53 Arg72Pro (rs1042522) and MDM2...

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Identifiers

PMID: 24175836
DOI: 10.7314/apjcp.2013.14.9.5415

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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