MDM2 SNP309 polymorphism is associated with colorectal cancer risk.

doi:10.1038/srep04851

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Article

MDM2 SNP309 polymorphism is associated with colorectal cancer risk.

Scientific reports - 6 May 2014

Wang Weizhi, Du Mulong, Gu Dongying, Zhu Lingjun, Chu Haiyan, Tong Na, Zhang Zhengdong, Xu Zekuan, Wang Meilin

Abstract excerpt

The human murine double minute 2 (MDM2) is known as an oncoprotein through inhibiting P53 transcriptional activity and mediating P53 ubiquitination. Therefore, the amplification of MDM2 may attenuate the P53 pathway and promote tumorigenesis. The SNP309 T>G polymorphism (rs2279744), which is located in the intronic promoter of MDM2 gene, was reported to contribute to the increased level of MDM2 protein. In this...

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Identifiers

PMID: 24797837
DOI: 10.1038/srep04851
PMCID: PMC5381279

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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