MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.

doi:10.1016/j.arcmed.2011.02.002

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Article

MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.

Archives of medical research - 1 Feb 2011

Liu Guo-Yuan, Jiang De-Ke, Shen Su-Qin, Yu Long

Abstract excerpt

BACKGROUND AND AIMS: The murine double minute 2 (MDM2) gene encodes a negative regulator of the tumor protein p53. A single nucleotide polymorphism (SNP) in MDM2 promoter, SNP309 T>G, has been reported to alter MDM2 protein expression and accelerate tumor formation in humans. Studies investigating the association between the polymorphism and human hepatocellular carcinoma (HCC) risk reported conflicting results....

Topics

Adult
Aged
Carcinoma, Hepatocellular
Case-Control Studies
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Liver Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Odds Ratio

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Proto-Oncogene Proteins c-mdm2

Risk Factors

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 21565629
DOI: 10.1016/j.arcmed.2011.02.002

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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