Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk.

PloS one - 1 Jan 2013

Qin Xue, Peng Qiliu, Tang Weizhong, Lao Xianjun, Chen Zhiping, Lai Hao, Deng Yan, Mo Cuiju, Sui Jingzhe, Wu Junrong, Zhai Limin, Yang Shi, Li Shan, Zhao Jinmin

Abstract excerpt

BACKGROUND: The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. The SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Studies investigating the association between MDM2 SNP309 polymorphism and colorectal cancer (CRC) risk reported conflicting...

Topics

Asian People
Colorectal Neoplasms
Genetic Association Studies
Humans
Odds Ratio
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2
Regression Analysis
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 24098760
DOI: 10.1371/journal.pone.0076031
PMCID: PMC3786895

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk.PMID 24098760Read ↗

MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk.Semantic proximity Read ↗

MDM2 SNP309 polymorphism is associated with colorectal cancer risk.Semantic proximity Read ↗

MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study.Semantic proximity Read ↗

MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism and hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

[Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.