Article
Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2013
Fu Qiang, Zhang Guoqiang, Chen Hongwei, Zheng Youwei, Cheng Jing
Abstract excerpt
It has been demonstrated that MDM2 is a well-established negative regulator of the p53 protein and might be associated with a significantly earlier age of onset of several tumors, including colorectal cancer (CRC). In recent years, a T to G substitution (SNP309) in the promoter of MDM2 has been extensively studied as a potential CRC risk factor; however, the results are inconsistent. To derive a more precise...
Topics
- Asian People
- Colorectal Neoplasms
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium
- Odds Ratio
- Polymorphism, Single Nucleotide
- Proto-Oncogene Proteins c-mdm2