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Article

[Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 May 2008

Liu Jun-Niao, Zhang Xue-Mei, Guo Yong-Li, Sun Tong, Lin Dong-Xin, Wen Tan

Abstract excerpt

OBJECTIVE: The tumor suppressor p53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage or oncogene activation. Mouse double minute 2 (MDM2) gene is a key negative regulator of p53 pathway and overexpressed in many cancers as oncoprotein. We have previously shown that genetic polymorphisms in the MDM2 promoter (309T --> G)...

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Source

Identifiers

PMID: 18953830

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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[Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population].PMID 18953830Read ↗

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MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis.Semantic proximity Read ↗

Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk.Semantic proximity Read ↗

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MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

[Association of murine double minute 2 and P53 polymorphisms with breast cancer susceptibility].Semantic proximity Read ↗

Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: An updated meta-analysis based on 59 case-control studies.Semantic proximity Read ↗

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Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish PopulationSemantic proximity Read ↗

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