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Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: An updated meta-analysis based on 59 case-control studies.

Gene - 15 Apr 2020

Elshazli Rami M, Toraih Eman A, Elgaml Abdelaziz, Kandil Emad, Fawzy Manal S

Abstract excerpt

OBJECTIVE: Several earlier reports implicated TP53 (rs1042522) and MDM2 (rs2279744) variants in outcome of colorectal cancer (CRC), but with inconclusive findings. This current meta-analysis designed to uncover the role of these variants in CRC risk. METHODOLOGY: Two independent investigators extracted 59 eligible case-control studies from different electronic databases involving Scopus, Web of Science and PubMed...

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PMID: 32001373
DOI: 10.1016/j.gene.2020.144391

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