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MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.

DNA and cell biology - 1 Mar 2012

Cao Xiangming, Zhang Tingrong, Zhao Zhen, Zhao Tao

Abstract excerpt

MDM2 is a phosphoprotein that interacts with p53 and inhibits its activity. Recently, a T to G substitution (SNP309) in the promoter of MDM2 was identified and associated with increased MDM2 expression and a significantly earlier age of onset of several tumors, including colorectal cancer. Several studies evaluated the association between SNP309 and colorectal cancer risk in diverse populations. However, the...

Topics

Colorectal Neoplasms
Humans
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21770737
DOI: 10.1089/dna.2011.1338

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.PMID 21770737Read ↗

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MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

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MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis.Semantic proximity Read ↗

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