Article
MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis.
BMC cancer - 29 May 2011
Wan Yan, Wu Wei, Yin Zhihua, Guan Peng, Zhou Baosen
Abstract excerpt
BACKGROUND: The tumor suppressor gene p53 is involved in multiple cellular pathways including apoptosis, transcriptional control, and cell cycle regulation. In the last decade it has been demonstrated that the single nucleotide polymorphism (SNP) at codon 72 of the p53 gene is associated with the risk for development of various neoplasms. MDM2 SNP309 is a single nucleotide T to G polymorphism located in the MDM2...
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