Article
Identification and preliminary characterization of protein-cysteine farnesyltransferase.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1990
Manne V, Roberts D, Tobin A, O'Rourke E, De Virgilio M, Meyers C, Ahmed N, Kurz B, Resh M, Kung H F
Abstract excerpt
Ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (Cys-186 in mammalian Ras p21 proteins) in order to exert their biological activity. Previous studies indicate that an intermediate in the mevalonate pathway, most likely farnesyl pyrophosphate, is the donor of this isoprenyl group. Inhibition of mevalonate synthesis reverts the abnormal phenotypes induced by the mutant...
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