Article
Farnesylation and proteolysis are sequential, but distinct steps in the CaaX box modification pathway.
Archives of biochemistry and biophysics - 1 Apr 1995
Farh L, Mitchell D A, Deschenes R J
Abstract excerpt
Membrane localization of Ras proteins requires posttranslational modification of a conserved C-terminal sequence motif known as the CaaX box (C is Cys, a is any aliphatic amino acid, and X is the carboxyl terminal residue). The modification steps include farnesylation, removal of the three C-terminal amino acids, carboxyl-methylation, and palmitoylation. In yeast, the farnesyltransferase (FTase) is encoded by the...
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