Article
Farnesylation and proteolysis are sequential, but distinct steps in the CaaX box modification pathway.
Archives of biochemistry and biophysics - 1 Apr 1995
Farh L, Mitchell D A, Deschenes R J
Abstract excerpt
Membrane localization of Ras proteins requires posttranslational modification of a conserved C-terminal sequence motif known as the CaaX box (C is Cys, a is any aliphatic amino acid, and X is the carboxyl terminal residue). The modification steps include farnesylation, removal of the three C-term...
Topics
- Alkyl and Aryl Transferases
- Amino Acid Sequence
- Animals
- Escherichia coli
- Farnesyltranstransferase
- Fungal Proteins
- Genes, Fungal
- In Vitro Techniques
- Molecular Sequence Data
- Mutation
- Peptides
- Protein Methyltransferases